The dynamic that created the Brexit vote is also at work in the US. That shouldn't be a shock. It is what drove both the Trump phenomenon (fascist anti-immigrant xenophobia), and what drove the Sanders campaign (rejection of neo-liberal, status quo, financial globalization).
Ian Welsh has probably best described Brexit, in a series of posts. Not just that one.
Since 1976 a lot of Britons who do not live in London (or not the nicer parts) have been doing very badly. The economy is trash if you aren’t connected to the various London money spigots because Britain insisted on de-industrializing. So, we have a very large number of people who have done very badly for 40 years. They were given an opportunity to vote against the status quo, and they did so.